Composition and methods for transdermal delivery of acid-labile drugs

Composition et procedes pour l'administration transdermique de medicaments labiles sous l'effet d'un acide

Abstract

A transdermal penetration-enhancing, drug acid-lability reducing composition and related method are described. Specifically, the transdermal composition comprises: (a) a therapeutically effective amount of a pharmacologically active drug which is subject to acid catalyzed degradation; (b) a pharmaceutically acceptable carrier substantially free of a lower alkanol; and (c) a penetration-enhancing amount of a functional derivative of a fatty acid. Such compositions increase the usefulness of transdermal compositions that rely upon an organic acid such as oleic acid penetration enhancer.

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