Process for the preparation of 2,5-disubstituted pyridines

Methode pour preparer des derives de disubstitution en 2,5 de pyridines

Abstract

The present invention concerns a process for the preparation of a 2,5-disubstituted pyridine of the formula (I) which comprises the steps of a) reacting a compound of the formula (II) with an acrylic compound of the formula (III) to form a compound of the formula (IV) and b) reacting the compound of formula (IV) under water free conditions with a hydrogen halide in which formulae R1 signifies lower alkyl, R2 signifies di-(lower alkyl)amino or a 5- or 6- membered -N-heterocyclyl group having the free valence bond at the nitrogen atom, and X signifies halogen.

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